From the concentration dependence of bsa apparent diffusion coefficients , protein interaction parameters have been regressed . it bears a net effective charge of - 9 . 0 and has a hamaker constant of 2 . 8ket 根据扩散系数随蛋白浓度变化的斜率与离子浓度变化的相关性,回归出了蛋白相互作用参数,蛋白所带的有效电荷zp二一9 . oe 、 hamaker常量= 2
Liposome is an effective nuclide delivery agent for neutron capture therapy . in this paper liposomes containing encapsulated gadolinium complex were prepared and characterized . the influence of formulation factors such as ph , ionic strength , buffer , and storage time upon the stability of liposomes was investigated . the uptake rate constant and its concentration dependence of lgd in tumor cells were compared in vitro with that of gd complex itself . the results indicate that the uptake rate of lgd in tumor cells increases to eight times as much as that of gd - edta , but the release rate of gd from tumor cells containing lgd is remarkably lower than that from the tumor cells containing gd - edta . the results reveal that lgd would be a potential drug for neutron capture therapy of cancer 制备和表征了包埋gd - edta的脂质体,测定了ph ,离子强度,缓冲液组成及温度对gd - edta脂质体的影响,比较了gd - edta脂质体和gd - edta被肿瘤细胞摄入的动力学曲线。结果表明, gd - edta脂质体在37和生理条件下最稳定,肿瘤细胞摄入gd - edta脂质体速率是gd - edta的8倍,而释放gd的速率, gd - edta脂质体远远低于gd - edta ,这些结果提供了脂质体包埋gd - edta作为钆中子俘获治疗药物的可能性。
The results show that effects of alkali metal salts on conductivity are different because of their different anion radium , crystal lattice energy , ionic mobility and solubility in electrolytes , that different ionic conduction modes of electrolytes result to double - peak of salt concentration dependence of conductivity and different temperature dependence , and that different influences of plasticizer to conductivity result from their different action 结果表明,不同碱金属盐对电解质电导率的影响因其阳离子半径、晶格能、离子淌度以及在电解质中的溶解度的不同而不同;电导率的盐浓度依赖性因电解质的离子传导方式不同而明显呈现双峰形;增塑剂对电导率的影响则因其作用方式不同而产生不同的效果;电导率的温度依赖性也因电解质的离子传导方式不同而呈现不同的规律。
The concentration dependence of bsa apparent diffusion coefficients was interpreted in the context of a two - body potential of mean force that includes repulsive hard - sphere and coulombic interactions and attractive dispersion : with increasing ionic strength , debye screening decreased , and protein interaction changed from repulsion to attraction , and protein aggregations was onset 利用平均势场理论的两体硬球相互作用模型解释了蛋白分子的相互作用变化规律:随着离子强度的增加,离子氛厚度减小,蛋摘要白分子间的相互作用由排斥变为吸引,蛋白开始聚集。
The internalization of oligochitosan in macrophage is a time - course process . 2 . initial experiments tested time , temperature , and concentration dependence of 2 - amac - oligochitosan uptake in macrophages . scatchard analysis of internalization of 2 - aminoacridone - oligochitosan in macrophages indicated its internalization is mediated by a specific receptor on macrophage membrane with ka of 2 . 1 10 - 5m 2 . 2一氨基叮睫酮标记的壳寡糖与巨噬细胞的结合是一个依赖时间、温度和浓度的过程, scatchard分析后发现它对巨噬细胞的作用是通过膜上特异性的受体( kd为2 . 1x10一sm )进行的。